What is Charcot Marie Tooth Disease or CMT?


Charcot-Marie-Tooth disease (CMT) is a group of inherited neurological disorders that affect the peripheral nerves—the nerves outside the brain and spinal cord that control muscle movement and sensation in the arms, hands, legs, and feet.


CMT is one of the most common inherited neurological disorders, affecting approximately 1 in 2,500 people worldwide.


Common Symptoms


Because CMT damages peripheral nerves, symptoms often include:


  • Muscle weakness in the feet, ankles, legs, and hands
  • Foot drop and difficulty walking
  • Balance and coordination problems
  • High arches or other foot deformities
  • Hand weakness and loss of fine motor skills
  • Numbness or reduced sensation in the hands and feet
  • Fatigue and muscle cramping


Symptoms typically progress slowly over time, although severity varies greatly from person to person.


What is CMT4C?


CMT4C is a rare subtype of Charcot-Marie-Tooth disease caused by mutations in the SH3TC2 gene.


People with CMT4C often experience:


  • Progressive muscle weakness
  • Balance and mobility challenges
  • Sensory loss
  • Scoliosis (curvature of the spine)
  • Increased need for mobility aids and assistive technology


CMT4C is inherited in an autosomal recessive pattern, meaning a person must inherit a copy of the altered gene from both parents.


Is There a Cure?


Currently, there is no cure for CMT, but treatments and supportive therapies can help maintain independence and quality of life. These may include:


  • Physical therapy
  • Occupational therapy
  • Orthotics and braces
  • Mobility devices
  • Assistive technology
  • Exercise and strength maintenance programs


The CMT Warrior Perspective


At CMT Warrior, we believe that a diagnosis should not define a person’s future. Through entrepreneurship, technology, education, advocacy, and creativity, we strive to demonstrate that people living with CMT can continue to build businesses, pursue careers, support their communities, and achieve meaningful goals.


CMT = Challenge. Warrior = Mindset.